Kevin Youkilis hit a grand slam, Paul Konerko homered and Dewayne Wise had four hits Tuesday night as the Chicago White Sox rallied for the second straight game to beat the New York Yankees 7-3.
Chicago, which fell behind 3-0 in Monday night's opener before winning 9-6, trailed 2-0 after one inning Tuesday in the matchup of division leaders.
Wise, designated for assignment by the Yankees in July, had four singles from the leadoff spot and has played well while filling in for the injured Alejandro De Aza.
With the game tied 2-2, the White Sox loaded the bases in the fifth inning on Alexei Ramirez's double, a walk and single by Wise. Youkilis connected off Ivan Nova for his second grand slam at U.S. Cellular Field this season. He also cleared the bases in April for the Red Sox against the White Sox and Phil Humber.
Since joining the White Sox in a June trade with Boston, Youkilis has hit 11 of his 15 homers.
Nova (11-7), who is 1-4 in his last eight starts, gave up seven hits and six runs in six innings.
Chicago's Francisco Liriano (5-10) also went six innings, surrendering Derek Jeter's leadoff homer and two runs in the first while allowing six hits and three walks.
Jeter hit the game's first pitch for his 12th homer, giving him sole possession of 11th place on the career hits list (3,256) and moving him ahead of Eddie Murray. The Yankees then loaded the bases on a single by Nick Swisher and two walks, but ended up with just one more run on Curtis Granderson's fielder's choice grounder as Liriano avoided a big inning.
Chicago got one back in the second on Alex Rios' triple and A.J. Pierzynski's sacrifice fly and then tied it on Konerko's 21st homer in the fourth.
Russell Martin hit his 14th homer, a solo shot off Jesse Crain, in the seventh. Gordon Beckham had a two-out RBI single in the eighth to restore the four-run lead.