An Upper East Side dermatologist who has appeared in newspapers, magazines and on television talk shows was arrested Wednesday in an alleged oxycodone scam. 

Dr. Cheryl Karcher was seen being led away in handcuffs Wednesday morning as law enforcement searched the Sadick Dermatology office on Park Avenue where she works. 

Investigators said Karcher allegedly wrote and filled hundreds of prescriptions for oxycodone under patients' names without their knowledge; she also allegedly used the names of former patients and acquaintances.

She allegedly lied to pharmacists, saying she was just performing a service for her patients, and used pharmacies near her residences in Manhattan and Connecticut.  

A 50-count indictment charges Karcher with criminal possession of a controlled substance, fraud and falsifying business records, among other crimes.

Karcher, whose Twitter bio states she is "a board certified dermatologist globally recognized as a leader in aesthetic medicine," pleaded not guilty at her arraignmenin Manhattan criminal court Wednesday afternoon. 

According to her Sadick Dermatology bio, Karcher is the consulting dermatologist to the Miss Universe organization and has appeared on CNN, as well as in Cosmopolitan, Fitness and Allure magazines.

Her attorney, Chuck Clayman, said his client plans to vigorously prepare for her defense.

An office manager at Sadick Dermatology said the office is cooperating with investigators. He added the office is open for other doctors and patients. 

Investigators in New York and Connecticut are looking into whether Karcher's alleged oxycodone fraud was to obtain drugs for personal use or for other means.  

The special narcotics prosecutor's office and drug enforcement agents lead the investigation.