Federal agents have seized 50 pounds of methamphetamine from a boardinghouse in Westchester County.
The Drug Enforcement Administration called it the biggest such bust in New York State history.
Officials said the drug was seized during a raid on the Church Street house in New Rochelle on Sunday.
It has a street value of $800,000.
DEA spokeswoman Erin Mulvey said two people were taken into custody.
Further details were not released.