Netflix said Friday night that Kevin Spacey will no longer be a part of "House of Cards" and it's cutting all other ties with the actor after a series of allegations of sexual harassment and assault.
"Netflix will not be involved with any further production of 'House of Cards' that includes Kevin Spacey," the company said in a statement.
Netflix said it will work with the show's production company MRC to evaluate whether it will continue without him.
The 58-year-old Spacey was nominated for best drama actor Emmy Awards during each of the show's first five seasons, but never won. He played a ruthless politician who ascends to the presidency of the United States. Co-star Robin Wright is also a central player on the show, and it could conceivably continue with a focus on her.
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Production on the show had already been suspended on Tuesday.
Netflix says it also will refuse to release the film "Gore," in which Spacey stars as the writer Gore Vidal and also acted as producer.
CNN reported that eight current or former "House of Cards" workers claim that Spacey made the production a "toxic" workplace and one ex-employee alleges the actor sexually assaulted him.
Spacey has not been arrested or charged with any crime. His publicist did not immediately return an email message late Friday night seeking comment. A publicist said earlier this week that Spacey is "taking the time necessary to seek evaluation and treatment."
The Academy Award-winning actor became ensnared in Hollywood's fast-growing sexual harassment crisis after actor Anthony Rapp alleged Spacey made sexual advances toward him in 1986, when Rapp was 14. Spacey has said he doesn't remember the alleged encounter reported by BuzzFeed News last weekend but apologized if such "drunken behavior" occurred.
The story spurred several others to come forward with similar allegations about Spacey.
London police are reportedly investigating Spacey for a 2008 sexual assault, British media reported Friday.
Police did not identify Spacey by name but said the department's child abuse and sexual offenses unit is investigating the reported assault after it was referred to police earlier this week.
Spacey is the latest high profile Hollywood figure to lose work and standing in a wave that began when dozens of sexual harassment allegations were reported last month against film mogul Harvey Weinstein.
Weinstein is under investigation in Los Angeles, Beverly Hills, London and New York for possible criminal cases after several women accused him of sexual assault or rape.
Also Friday, Hamilton Fish, publisher of The New Republic, resigned amid allegations of sexual harassment.
In a company memo shared with The Associated Press, magazine owner Win McCormack wrote that Fish's resignation was effective immediately and that an internal investigation would continue. Fish, who joined The New Republic in 2016, had been placed on leave of absence last week. He is a former publisher of The Nation.
"As I understand it, some employees, to my deep dismay, complained this week that my presence had led them to feel uncomfortable at The New Republic," Fish wrote to McCormack in a memo Friday that was also shared with the AP. "Women have longstanding and profound concerns with respect to their treatment in the workplace. Many men have a lot to learn in this regard. I know I do, and I hope for and encourage that new direction."
Fish wrote in an email to the AP that he "felt the controversy swirling around us could cause irreparable harm to the magazine, and that the only way to protect The New Republic and its employees was for me to separate from the organization." Noting his time with such organizations as The Nation, a prominent liberal publication, and with Human Rights Watch, he wrote that he had spent his career in "in progressive media and the human rights field.
Fish is among several figures in media and publishing that have stepped down or been fired in the wake of the Weinstein reports.
Others include author and former NBC analyst Mark Halperin, former New Republic literary editor Leon Wieseltier and former NPR chief editor Michael Oreskes, who was an AP executive from 2008 to 2015.
AP National Writer Hillel Italie in New York and Writer Gregory Katz in London contributed to this report.