Mark Trumbo hit two home runs, Chris Tillman scattered five hits over seven innings and the Orioles extended the Yankees' losing streak to six games with a 4-1 victory Tuesday night.
Trumbo hit a solo shot in the second inning and his eighth of the season with a runner on in the fifth. Both homers were off Luis Severino (0-4), who yielded only two long balls in his previous four starts.
Tillman (3-1) allowed one run, matched his career high with nine strikeouts and walked four. The right-hander also fanned nine in his last start, against Tampa Bay.
Brad Brach worked the eighth and Darren O'Day finished for his second save.
Didi Gregorius drove in the lone run for the last-place Yankees, whose six-game skid matches their longest of last season. New York fell to 8-16, including 3-9 on the road, their worst 24-game start since 1991.
Severino allowed four runs, three earned, and five hits over six innings. He also made two identical errors, mishandling a soft throw from Mark Teixeira while moving to cover first base.
Manny Machado started at shortstop for the Orioles in place of J.J. Hardy, who was put on the 15-day disabled list before the game with a broken bone in his foot. Machado, an All-Star third baseman, handled the middle of the infield flawlessly while Ryan Flaherty effectively manned third.
Machado showed his range in the fifth inning, when he went far to his left to snag a grounder on the outfield grass before spinning around and throwing out Alex Rodriguez at first base.
Rodriguez, the designated hitter, pulled up to the base slowly and was replaced by a pinch-hitter the next time he was scheduled to hit.
A run-scoring single by Gregorius put New York up 1-0 in the second, but the advantage lasted only until Trumbo connected in the bottom half of the inning. The Yankees have held the lead in all but five of their games this season.
Severino's second error, following a diving stop by Teixeira, enabled the Orioles to take a 2-1 lead in the fourth.
One inning later, Trumbo completed his ninth career multihomer game — the second this season.
Yankees: Four-time All-Star closer Aroldis Chapman, suspended 30 games by Commissioner Rob Manfred for violating MLB's new domestic violence policy, will probably throw two more times in extended spring training before joining the club, manager Joe Girardi said, adding, "May 9th, he's ready."
Orioles: Closer Zach Britton (ankle) hopes to return to action this week, perhaps as soon as Tuesday. He was injured Saturday. ... RHP Yovani Gallardo, who's been on the DL since April 23 with shoulder tendinitis, is "moving toward throwing before too long," manager Buck Showalter said.
Yankees: CC Sabathia (1-2, 5.06 ERA) makes his fifth start of the season Wednesday night in the second game of the series. The left-hander is 18-7 lifetime against Baltimore but winless in his last eight starts at Camden Yards.
Orioles: RHP Tyler Wilson (1-0, 3.06 ERA) starts for the eighth time in his career. Sabathia made his eighth start in 2001.