Authorities snagged 45 pounds of cocaine during a routine bag inspection at Newark Liberty International Airport.
Officials say the drugs, worth more than $2 million on the street, arrived aboard a flight from the Dominican Republic in an untagged duffel bag June 11.
No one attempted to claim the bag and no one was arrested.
The 35 brick-shaped objects containing the cocaine were detected during X-ray inspections.
The Newark-area seizure was the second of the week for U.S. Customs and Border Protection agents. They seized 84 pounds of cocaine at the Port of Newark during a routine search of a metal shipping container from Panama on June 8. Those drugs had a street value of more than $4 million.
Earlier this year, a huge shipment of cocaine was detected in produce cans.