A North Texas family is touting a "miracle oil" and praising researchers at UT Southwestern Medical Center in Dallas for healing their little girl, who was having chronic seizures.
Spend a day with 6-year-old Chloe Olivarez and it is hard to keep up with her. Chloe's mother, Brandi Olivarez, says she never thought she would see this day.
"I don't even know that a year ago she would have been able to," Olivarez said.
Just two years ago, Brandi Olivarez had no idea what was wrong with her daughter. Video from Children's Health in Dallas shows doctors monitoring Chloe to figure out why she was having hundreds of seizures a day.
"We were looking at buying a wheelchair and diapers, because she wasn't able to be potty trained at that point," Brandi Olivarez said.
A helmet protected Chloe's head because she fell often.
"We were watching her go down this progressive slope, and she was just continually declining," Brandi Olivarez said.
Tests revealed Chloe had Glut 1 deficiency. That is a metabolic disease that depletes the brain of needed glucose, which makes most people unresponsive and slow to develop.
"It was kind of bittersweet. Finally understanding what she actually had, what we were fighting and the next step. It doesn't have a cure," Brandi Olivarez said.
But their timing was impeccable. Dr. Juan Pascual, a professor of pediatric neurology at UT Southwestern Medical Center, had just wrapped a groundbreaking study on mice with Glut 1, using an edible oil.
Pascual enrolled Chloe in his first human clinical trial, and within hours of ingesting the oil, her seizures started to subside.
"I had never seen anything like it," Pascual said.
"Speech was the first, other than seeing the seizure activity on the EEG, you could tell. She wasn't having seizures where she was hitting the floor anymore, and then speech was the next thing. Her speech, she immediately started using sentences," Brandi Olivarez said. "So then. with prolonged use, we have increased muscle tone. She's about to run a mile without stopping now."
The medicinal oil is derived from castor beans called Triheptanoin, which is used in many cosmetics in the United States. It has no smell and no taste.
All 14 participants in the study drank the oil four times a day in varying doses, and 70 percent of them saw a significant decline in seizures and improved neuropsychological performance.
The study is published in JAMA Neurology.
"Some days are very rough and some days are very happy, and I have to say that this was one of the happiest days of my life," Pascual said.
Chloe's family says watching her progress has been remarkable.
"We owe him everything. Now, we have a very vibrant, sassy little girl and I can't express my gratitude for everything they've done for us because it's been amazing to watch her," Brandi Olivarez said.