This "Pretty Woman" has the mouth of a truck driver.
Roberts couldn't stop the profanity from pouring out at the event, an honorary celebration of friend and fellow actor Tom Hanks' film career.
"All right, well, it's late, and I'm paying my babysitter overtime, and I have to pee," she said at the beginning of her speech. "So Tom, everybody f---king likes you. All my bits are gone."
The "Erin Brockovich" actress went on to lampoon Hanks' performance in his less successful films, cracking R-rated jokes about his box-office flops.
"I love the Coen brothers, but the hair, Tom, I didn't even know what the f--k that movie was about," she said of 2004's "The Ladykillers."
Roberts, who wore a cream-colored gown, said during her address to Hanks that she'd committed a major fashion faux pas.
"God, I'm wearing the same f---king dress tonight as your publicist!" Roberts said onstage.
The starlet with a million-dollar smile "has the biggest potty mouth you have ever heard," Hanks said after Roberts' speech.
Charlize Theron and Bruce Springsteen were part of the crowd that heard Roberts' swear-word storm.