Robinson Cano homered twice and hit one of three straight long balls off an ineffective Johan Santana to lead the New York Yankees to a 9-1 rout of the Mets on Friday night.
Hiroki Kuroda allowed one hit in seven scoreless innings before leaving with a bruised left foot. Cano ended Santana's bid for a second straight no-hitter with a two-run shot in the second, then connected again in the third to begin a string of three consecutive home runs by the Yankees.
In the first Subway Series matchup of the season, Kuroda (5-6) gave up only a two-out double in the sixth to Omar Quintanilla.
Santana (3-3) was given two extra days of rest after throwing a career-high 134 pitches last Friday against St. Louis in the first no-hitter in Mets history. But he didn't have it this time, serving up a career-high four homers during New York's fourth loss in five games
Kuroda's first appearance in the crosstown rivalry was cut short when Daniel Murphy scorched a liner off the pitcher's foot, eliciting "oohs" from the crowd of 48,566 — just the second sellout at Yankee Stadium this season. The ball popped up high and was caught by third baseman Alex Rodriguez for the final out of the seventh.
Kuroda limped off the field and down into the clubhouse, followed by several teammates and trainers.
Cody Eppley worked the eighth and former Mets reliever Ryota Igarashi gave up an RBI double to Lucas Duda in the ninth in his Yankees debut before finishing the two-hitter.
With Jose Reyes in Miami, Mariano Rivera preparing for knee surgery and Kuroda on the mound, the start of 16th Subway Series had a different look. The Mets, who slashed $49 million from their payroll last offseason, have a roster full of youngsters participating in their first game between the New York teams.
Sam "The Bugler" Grossman, who will play Saturday at the Belmont Stakes, gave a new take on the national anthem. I'll Have Another's trainer, Doug O'Neill, was scheduled to throw out the ceremonial first pitch along with the horse's owner, Paul Reddam, and jockey Mario Gutierrez, but they pulled out after the colt was scratched from making a Triple Crown bid because of injury.
Little else changed, though.
The Yankees tagged Santana at the new Yankee Stadium again, improving to 50-35 against the Mets in the regular season.
After a perfect first inning, Santana walked Rodriguez to start the second, his last two pitches missing badly. Cano lined the next pitch into the right-field seats for the first runs off Santana since May 21, three starts ago. He had a scoreless streak of 19 innings.
Rodriguez singled with two outs in the third. Cano then set off a barrage of long balls in an 11-pitch span with a drive into the second deck in right, again on a first pitch, for his eighth multihomer game.
Nick Swisher followed with a liner to left field and Andruw Jones hit a high-arcing drive to left for a 6-0 lead. It was the first time Santana allowed three homers in a row.
Cano had two tries for a third homer but popped out and grounded out.
There was no need to worry about a pitch count for Santana. He was lifted after five innings, having allowed six runs and seven hits. He threw 86 pitches.
The two-time Cy Young Award winner has given up 19 earned runs in 14 innings and is 0-3 in three starts at the new ballpark in the Bronx.
Kuroda had a poor history against the Mets, going 1-5 with a 5.75 ERA against them with the Los Angeles Dodgers.
This time he had the Mets flailing at a slider that fooled lefties and righties. There wasn't a hard-hit ball until Quintanilla's double. The most difficult play came after Josh Thole reached on Derek Jeter's error at shortstop. David Wright broke his bat near the handle, sending much of it spiraling toward Rodriguez, while hitting a grounder to third. A-Rod calmly fielded the ball and started a double play as the bat soared over his head.
Kuroda has made three solid starts in a row, giving up just two runs in 22 innings. This time he struck out seven and walked one.
Swisher had an RBI double and Jones a run-scoring single in a three-run seventh.