Police acknowledged that arrests were made, but would not disclose the exact number.
Witnesses and protesters told NBC New York that at least 50 people were arrested -- so many that the police brought in MTA buses to bring them to the local precinct. Most of the arrests took place on East 12th Street and Fifth Avenue before the protest continued to Union Square.
The protest began last Saturday as hundreds of people set up camp near the New York Stock Exchange to target financial firms.
Among other things, they questioned political connections between Washington lawmakers and giant moneymaking companies, as well as the government bail out of Wall Street.
Five people were arrested last week on disorderly conduct, and for breaking an old law that forbids protesters from wearing masks.