The accident happened on the 1800-block of Marmion Avenue, off East 175th Street. Two vehicles appear to have collided head-on, causing one of them to veer off to the sidewalk and into a building.
Firefighters used the Jaws of Life to pry open the car that went into the building and removed two occupants, reports News Chopper 4's Dennis Prostko.
Crews have also been cleaning up small fuel spills resulting from the crash.
Three people so far appear to have been injured.
This story is developing. Check back for updates.