New information that surfaced several months ago "reinvigorated" the case, leading the LAPD to take another look at the slaying of "The "Ready to Die" star, a law enforcement told CNN.
Smalls, 24, born Christopher Wallace and also known as the Notorious B.I.G., was gunned down in L.A. while driving away from a VIBE magazine album release party at the Petersen Automotive Museum on March 9, 1997.
LAPD suspect the killer was a lone gunman in a Chevy Impala who sprayed Biggie's Suburban. Witnesses described the gunman as an African-American man wearing a suit and a bow-tie.
The sources said they could not discuss or describe the new information, citing the ongoing investigation. Also aiding in the investigation: the L.A. County District Attorney and the FBI.
Investigators long suspected that Smalls was killed in a East Coast/West Cost rivalry between rappers, which also claimed the life of Tupac Shakur six months before -- and his slaying also remains unsolved.
Wallace's family sued the LAPD in 2006, alleging a cover-up; the suit was dismissed last year.
Los Angeles City Councilman Bernard Parks, who was chief of police at the time, said allegations of a police cover-up were "absurd."