Rose Byrne, who played Kristen Wiig’s nemesis in the 2011 big-screen hit “Bridesmaids,” will make her Broadway debut in Moss Hart’s and George S. Kaufman’s Pulitzer Prize-winning ensemble comedy “You Can’t Take It With You.” The revival, directed by Scott Ellis (“The Mystery of Edwin Drood”), kicks off previews Aug. 26 ahead of a Sept. 28 opening at the Longacre Theater.

The actress will play Alice, the youngest daughter of the eccentric Sycamore clan, lead by James Earl Jones as the family’s patriarch. Tensions rise when Alice invites her fiancé and his uptight family to meet the Sycamores, a wild bunch made up of snake collectors, artists, dancers, and rocket makers.

In addition to Byrne and Jones, “You Can’t Take It With You” also includes two 2013 Tony nominees: Kristine Neilsen (“Vanya and Sonia and Masha and Spike") and Annaleigh Ashford (“Kinky Boots,” TV’s “Masters of Sex”). Mark Linn-Baker (TV’s “Perfect Strangers”), Crystal A. Dickinson (“Clybourne Park”), Reg Rogers (“The Royal Family”), Marc Damon Johnson ("Lucky Guy"), Patrick Kerr (“Frasier”) and Julie Halston (Bitsy von Muffling from “Sex and the City”) make up the rest of the cast.

Byrne received two Golden Globe and Emmy nominations for her role on TV’s “Damages." She's currently appearing alongside Seth Rogan and Zac Efron in the box-office hit summer comedy “Neighbors.". This year, Byrne will also be seen in “This Is Where I Leave You,” with Tina Fey and Jason Bateman, and the reboot of the smash stage musical “Annie,” costarring Cameron Diaz and Jamie Foxx.